Here are some links that help you figure out what vaccinations you made need to travel to Mexico. Best bet though is to call your doctor's office.
http://www.cdc.gov/travel/camerica.htm#vaccines
Note: I have heard that some palces say you'll need proctection against Malaria in Zacatecas, please ask your doctor for recommendations about being vaccinated against Malria. Also, will we have mosquito nets just in case. I will take care of getting these for us.